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Mandolin

Also known as: mandolin.com

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AI agents that run the back office for specialty drugs: Mandolin reads referrals into the EHR, investigates benefits on payer portals and by phone, checks charts against medical policy and submits prior authorizations by portal, fax or phone for infusion centers and specialty pharmacies.

Mandolin works the gap between a prescription for an infused or injected specialty drug and the patient's first dose. Its agents read referral forms, lab reports and clinical notes in any format and enter them into the EHR, run full benefits investigations by navigating payer portals and calling payers, and estimate what the patient will owe from benefits, site fee schedules, copay assistance, GPO and 340B pricing and drug acquisition cost. They then compare the payer's medical policy with the chart, compile and submit the prior authorization by portal, fax or phone, check claim status and interpret remits.

The agents need no API or EHR integration. They log into the clinic's own systems and work the way trained staff do, and every action is logged and traceable, with safety checks and human oversight. Customers include Vivo, Amber Specialty Pharmacy and national ambulatory infusion groups, across hundreds of clinic, infusion suite and specialty pharmacy locations.

Pricing is by quote. Mandolin, legally Coral Automation, Inc. of San Francisco, raised $40 million across a seed co-led by SignalFire and Maverick and a Series A led by Greylock, announced in June 2025.

Vendor details

Canonical URL

https://www.mandolin.com

Category

Healthcare agent

Subcategory

AI agents for specialty drug access: intake, benefits, medical policy review, prior authorization and claims

Funding status

$40M raised: seed co-led by SignalFire and Maverick with Timeless, SV Angel and founders of Vercel, Decagon and Yahoo, then a Series A led by Greylock, announced June 2025. Legal entity Coral Automation, Inc., San Francisco.

Company status

independent

Use cases & customers

Primary use cases

referral intake into the EHRbenefits investigation on payer portals and by phonepatient out of pocket estimates for specialty drugsmedical policy review and prior authorization submissionclaim status checks and appeals

Target customers

infusion centers and ambulatory infusion groupsspecialty pharmacieshealth system specialty drug programsspecialty practices that buy and bill infused or injected drugs

Deployment options

SaaS

Integrations

No APIs or integrations are required. Mandolin's agents log into the customer's EHR, payer portals and other systems with their own access and work them like staff, and use fax and outbound phone calls with payers. There is no connector catalogue or list of supported EHRs.

In practice

A referral for an infused MS therapy arrives by fax with lab reports attached. Mandolin reads it, enters the patient into the infusion center's EHR, runs the benefits investigation on the payer portal and calls the payer when the portal falls short.

The payer requires prior authorization. Mandolin checks the chart against the medical policy criteria, compiles the packet and submits it through the payer's portal, then follows the request until a decision arrives.

A specialty pharmacy has a backlog of new prescriptions. Mandolin processes intake as prescriptions arrive, so staff work only the cases that need judgment.

Agentic Index coverage score

5.0 / 14 capabilities · 36%

Integrations & Tool Calling Partial

Payers are reached through their portals, by outbound phone calls and by fax, and referral data goes into the customer's EHR. No APIs or integrations are required, and there is no connector catalogue, list of supported EHRs or way to add tools. The agents reach those systems by logging in and working their screens the way staff do, which is how one national infusion group now moves 250 documents a day into its EHR in under two hours each, against up to three days before.

Sourcemandolin.comread 2026-10-09

Workflow Orchestration Full

One patient moves through a chain of stages run by the agents: intake and onboarding into the EHR, a full benefits investigation, the patient's out of pocket estimate, medical policy review against the chart, prior authorization submission, then claim status checks, remit interpretation and appeals. Mandolin calls the layer underneath its Agentic Operating System and says it keeps one context across structured records, clinical notes, imaging and payer policy so each decision draws on the same picture of the patient.

Sourcemandolin.comread 2026-10-09

Knowledge Grounding & RAG Partial

Before submitting, the agents compare each payer's medical policy requirements with the patient's chart, weaving structured records, clinical notes, imaging and medical literature into one workflow. Policy review runs case by case, without a standing payer policy library offered to customers. Mandolin's own writing on the subject, by a former infusion operations leader, recommends tracking each payer's live policy pages rather than saved PDFs, because payer policies change once or twice a year, often by tightening details such as a lab draw window.

Sourcemandolin.comread 2026-10-09

Human Oversight & Guardrails Partial

Strict safety checks with human oversight guard every action, by Mandolin's account, and customers describe staff refocused on complex cases while the agents take routine ones, as when a national infusion group moved 13 outsourced roles onto exceptions. There is no approval queue or setting that lets a clinic hold a submission before it goes out, so oversight rests on Mandolin's own checks.

Sourcemandolin.com/post/40-million-to-obliterate-specialty-drug-paperworkread 2026-10-09

Security, Identity & Governance Not documented

Mandolin keeps its security documentation in a gated trust center at trust.mandolin.com, so its certifications and access controls are not visible from outside. The product site itself commits only to the agents acting in line with payer requirements and healthcare regulations.

Sourcetrust.mandolin.comread 2026-10-09

Observability & Auditability Partial

Every action the agents take is logged and traceable, and Mandolin positions each as transparent, auditable and aligned with payer requirements and healthcare regulations. Where that log lives, what it records and whether a clinic can open and search it are unclear.

Sourcemandolin.comread 2026-10-09

Memory & State Persistence Not documented

Mandolin keeps a universal context across each patient's journey, so intake, benefits and authorization work draw on the same picture of the patient. There is no memory store with its own scope or lifetime beyond that, and the records the agents work from are the customer's own EHR and payer data.

Sourcemandolin.com/post/40-million-to-obliterate-specialty-drug-paperworkread 2026-10-09

Deployment & Data Residency Not documented

The service is hosted, and its agents log into the customer's existing systems from there. No hosting provider or region, region choice or option to run inside the customer's environment is named.

Sourcemandolin.comread 2026-10-09

Prebuilt Agents / Templates / Packs Not documented

The whole specialty drug lifecycle is sold as one AI back office, with intake, benefits, cost estimates, policy review, authorization and claims as its stages. There are no separately sold agents, templates or library for a customer to pick from, so a buyer takes on the full workflow rather than a single task.

Sourcemandolin.comread 2026-10-09

Triggers & Channel Coverage Full

Work begins as documents arrive. Referral forms, lab reports and clinical notes are read and acted on in whatever format they come, and a specialty pharmacy customer reports new prescriptions now processed in real time with no backlog. After submission, claim status is checked automatically through portal checks or payer calls, with remits interpreted as they return.

Sourcemandolin.comread 2026-10-09

Model Flexibility & Routing Not documented

The agents draw on the latest advances in vision, language and multimodal reasoning, according to the company, but the models themselves are undisclosed. Customers get no choice of model.

Sourcemandolin.com/post/40-million-to-obliterate-specialty-drug-paperworkread 2026-10-09

APIs / SDKs / MCP Extensibility Not documented

Mandolin is built to need no APIs or integrations on the customer's side, and it has no public API, SDK or MCP server of its own for customers or partners to build on.

Sourcemandolin.comread 2026-10-09

Testing, Debugging & Optimization Not documented

Customer results carry the case for the agents, such as intake falling from 20 minutes to 3 minutes a document and a top 20 specialty pharmacy clearing a four day prescription backlog. There is no evaluation harness, test set or accuracy measure a customer can run against the agents before or after a change.

Sourcemandolin.comread 2026-10-09

Browser / Computer-use Full

The agents log into the clinic's EHR and payers' portals and work them like a staff member, with no API or EHR integration behind them. Mandolin describes them as software that can reason, click, call and follow up: navigating payer portals for eligibility, entering referral data into the EHR and submitting prior authorizations through portals.

Sourcemandolin.comread 2026-10-09

The Agentic Index coverage score grades every vendor Full, Partial or Not documented against the same 14 buyer facing capabilities, from public evidence only. Each capability links to how all vendors in the index score on it. How this evidence is graded

Pricing

Contact for pricing

Set in the quote

Included quota

Set in the quote.

What is public

Nothing about price is published. The homepage offers a contact form.

Billing mechanics

Billing terms are set in the quote.

Cost watchouts

Agents that log into your systems need their own credentials and access on every EHR and payer portal they work, which is setup work on your side.

Variable cost rationale

Mandolin quotes each deal, so whether cost follows referrals, authorizations, documents or seats is unknown.

Additional watchouts

The agents work under credentials on your EHR and payer accounts, so plan how those logins are provisioned, scoped and audited before go live.

Overage / add-ons

Overage terms come with the quote.

Sales call required

Yes, required for paid access

Free / trial

No free plan or trial

Lowest paid plan

None public; pricing is quoted by sales

Commercial notes

Mandolin, legally Coral Automation, Inc. of San Francisco, sells to infusion centers, specialty pharmacies and health systems. Greylock led its Series A after a seed co-led by SignalFire and Maverick, for $40 million in total.

Key ambiguities

Whether Mandolin charges per patient, per transaction or for the whole back office is unclear.

Missing data

Price, billing unit, minimums, contract terms and implementation fees.

Agentic Index verified 2026-10-09

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